MIAMI -- The San Francisco 49ers, who have been playing since 1946, are on the verge of taking their losing to a new level.A loss Sunday at Miami would be the 49ers 10th in a row, a franchise record. The lone victory came 2+ months ago in the season opener, and their 1-9 record has earned them the nickname the one-and-Niners.If fans dont take them seriously, how can the Dolphins?The challenge is if the players read the paper or watch the news, Miami offensive coordinator Clyde Christensen said. We always really emphasize, `Just worry about us. Dont worry about the opponent. Its just a nameless, faceless opponent. Lets go play good football. If we do, things are going to be OK.That approach has worked just fine in recent weeks for the Dolphins (6-4), who try Sunday for a sixth consecutive victory , which would be their longest winning streak in 11 years.Here are things to know about the matchup between teams headed in opposite directions:GREAT EXPECTATIONS: No team is a bigger favorite Sunday than Miami, heady stuff for a franchise that hasnt made the playoffs since 2008.Hopes of ending the drought are on the rise, even though the Dolphins havent exactly dominated, coming from behind in the fourth quarter of each of their past four games. And a wave of injuries has left the offensive line in a mess .But the players deny theyre susceptible to an upset against the woeful 49ers.I dont think its a trap at all, running back Jay Ajayi said. All were looking at is the Niners. The playoffs are so far away. With records, you can buy into all that stuff, but we were 1-4 a few weeks ago. So when we turn on the tape, we see a team that plays hard and is a physical team, and they have talent over there. Well be ready to play.Credit Ajayi for finding ways to compliment a team that ranks last in the NFL in defense, last in run defense and third worst in offense. They 49ers are 0-5 since Colin Kaepernick took over at quarterback for Blaine Gabbert.Ultimately we have to be the ones that change the outcome of these games and change the path that were on, Kaepernick said. We have to stay focused on that task, and not let what has happened in the past affect that.TALE OF TWO HALVES: Kaepernick has been a completely different quarterback in the first half than the second. He has started fast, completing 73.5 percent of his passes with 11 yards per attempt, six TDs, two interceptions and a 126.2 passer rating in the first two quarters. He has fallen off after that, completing 38 percent with 4.2 yards per attempt, one TD and a 55.2 rating in the second half.We have to execute in the second half, coach Chip Kelly said.BIG VOID: The Niners struggling defense lost another key player when safety Eric Reid went down with a season-ending biceps injury. He joins LB NaVorro Bowman (Achilles tendon tear) and DL Arik Armstead (shoulder) on IR for a defense that has allowed the second-most yards and points this season.Reid is particularly hard to replace because of his versatility. He has lined up at inside and outside linebacker, covered tight ends and played both safety positions. He ranks second on the team with 62 tackles. Second-year safety Jaquiski Tartt will be called on to replace Reid.Hes got great range and ball skills, coordinator Jim ONeill said. Hes got a knack for reading the quarterback.WATCHING THE HIGHLIGHTS: Ajayis productivity has declined each of the past three weeks, but he leads all running backs with an average of 5.6 yards per carry and confesses to enjoying replays of his breakaway runs in team meetings.Its fun watching the tape, because during the play you dont really know everything thats going on, he said. I kind of black out during plays anyway. So its always cool watching the big plays over and seeing the little things -- the receivers extra effort, and people on the sideline getting excited.PENALTY PROBLEM: The Dolphins rank second in yards penalized with 77 per game, and theyve been flagged 40 times in the past four games. The coaching staff shrugs off some penalties -- but not post-whistle personal fouls, which have been a problem.Its a fine line. We like how theyre playing. We really like the aggressiveness, Christensen said. But losing your poise will lose games. Were getting to a point where a mistake can eliminate you from contention or from a playoff game.---AP Sports Writer Josh Dubow in San Francisco contributed to this report.---For more NFL coverage: http://www.pro32.ap.org and http://www.twitter.com/AP-NFL.---Follow Steven Wine on Twitter: http://twitter.com/Steve-Wine. His work can be found at http://bigstory.ap.org/content/steven-wine Nelson Cruz Jersey . He was followed closely by David Clarkson, donning red, seconds later. Clarksons actions one night earlier, leaping off the bench in defence of Kessel during a pre-season game against the Buffalo Sabres, will cost him the first 10 games of the regular season. Randy Johnson Jersey .com) - The Calgary Flames aim to bounce back from their first regulation home loss of the campaign on Friday night when they host a Detroit Red Wings club that they swept in three meetings a season ago. http://www.cheapmarinersjerseys.com/ . Listen to the game live on TSN Radio 1050 at 7pm et. 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East Carolina and UNLV are out of the Big 12s expansion derby.Officials at both schools said Wednesday that they were notified by the Big 12 that they are no longer being considered for membership.East Carolina spokesman Tom McClellan says Commissioner Bob Bowlsby notified Chancellor Cecil Staton of the leagues decision Tuesday by phone.Athletic director Jeff Compher says its obviously not the decision we were hoping for, but expressed satisfaction that we were able to tell our story to not only the Big 12, but the entire nation.East Carolina is beginning its third season in the American Athletic Conference after winning two Conference USA championships in football in the 2000s.UNLV President Len Jessup and athletic director Tina Kunzer-Murphy issued a statement later in the day to acknowledge the Rebels were no longer being considered. UNLV has been a member of the Mountain West Conference since 1990.As the landscape of intercollegiate athletics continues to change, ensuuring UNLV is properly positioned and is a member of a conference that is the best fit for our university and community remains part of our long-term vision, the statement said.dddddddddddd We remain committed to fulfilling our responsibility to be a strong and successful member of the Mountain West.Its not yet clear if any other schools have received similar notification from the league, which announced July 19 that its presidents had authorized Bowlsby to begin evaluating schools for possible expansion of the 10-team conference by two or four members.The conference has not commented publicly on its plans nor has it committed to adding schools.Bowlsby has put no timetable on the Big 12s decision, though he has said the conference would like to move quickly and not interfere with the football season. The presidents meet again in early October. 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